GSK-3β在HBV相关肝细胞癌中的作用

肝脏 ›› 2022, Vol. 27 ›› Issue (9): 1041-1044.

GSK-3β在HBV相关肝细胞癌中的作用

张丹眉, 石春霞, 龚作炯

430060 湖北武汉大学人民医院感染科

收稿日期:2021-10-30 出版日期:2022-09-30 发布日期:2022-10-27
通讯作者: 龚作炯,Email: zjgong@163.com
基金资助:
国家自然科学基金资助项目(82070609)

Received:2021-10-30 Online:2022-09-30 Published:2022-10-27

摘要/Abstract

摘要： 乙型肝炎病毒(hepatitis B virus, HBV)感染是肝细胞癌发生的最主要原因,尽管治疗方式多样,但其复发率高仍是肝细胞癌治疗的重大难题。本综述主要通过总结HBV感染后糖原合成酶激酶-3β(glycogen kinase synthase-3β,GSK-3β)分子的上游调节因子和下游靶向分子,介绍GSK-3β在HBV感染相关的肝细胞癌发生发展中的作用,阐述靶向GSK-3β分子方法在延缓乙型肝炎进展,降低乙型肝炎病毒引起肝细胞癌发生率中潜在的价值。

张丹眉, 石春霞, 龚作炯. GSK-3β在HBV相关肝细胞癌中的作用[J]. 肝脏, 2022, 27(9): 1041-1044.

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