固有淋巴样细胞抗肿瘤免疫新进展

摘要/Abstract

摘要： 固有淋巴样细胞(innate lymphoid cells)即ILCs,是近年来发现的一类缺乏抗原特异性受体的非T、B淋巴细胞的淋巴细胞群体。ILCs根据不同细胞标记可将其分为不同的亚群,各类亚群参与固有免疫反应,并通过直接或间接的作用介导适应性免疫。ILCs的可塑性及和细胞间的相互作用,调控各类疾病的发生、发展,也在抗肿瘤免疫中发挥双向作用。了解ILCs的多样性、异质性及其独特功能路径,有助于为免疫治疗提供新思路新方法。

关键词: 固有淋巴样细胞, 固有免疫, 抗肿瘤免疫, 肝细胞癌

王妍雯, 强思远, 付阳荷, 何嘉音, 杨乐晨, 齐洁, 戴雪瑜, 李斌. 固有淋巴样细胞抗肿瘤免疫新进展[J]. 肝脏, 2022, 27(12): 1252-1257.

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