载脂蛋白E基因多态性与肝脏疾病的研究进展

摘要/Abstract

摘要： 脂肪性肝病、病毒性肝炎等慢性肝病进一步可发展为肝纤维化、肝硬化甚至肝癌,严重损害肝功能。90%的载脂蛋白E(ApoE)在肝脏合成,ApoE有三个等位基因、6个基因型、3种表型(E2、E3、E4),其基因多态性在肝脏疾病的发生发展中起着重要作用。研究探明影响肝脏疾病的基因及基因型,将为肝脏疾病的诊断、个体化治疗及预防提供重要理论依据。本文就ApoE在不同肝脏疾病中的研究现状进行综述。

关键词: 载脂蛋白E, 基因多态性, 脂肪性肝病, 病毒性肝炎, 肝纤维化, 肝硬化, 肝细胞肝癌, 肝移植

贾刚刚, 王俊科, 何昱静, 于晓辉, 卢利霞. 载脂蛋白E基因多态性与肝脏疾病的研究进展[J]. 肝脏, 2023, 28(2): 250-253.

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