多模态影像技术联合超声剪切波弹性成像对代谢相关性脂肪性肝病的诊断价值

肝脏 ›› 2023, Vol. 28 ›› Issue (9): 1101-1104.

多模态影像技术联合超声剪切波弹性成像对代谢相关性脂肪性肝病的诊断价值

杨孺牛, 符进, 王德琴

226600 南通大学附属海安医院放射科(杨孺牛),超声科(符进),内分泌科(王德琴);

收稿日期:2022-08-28 出版日期:2023-09-30 发布日期:2023-10-24
通讯作者: 杨孺牛,Email:guohongser@163.com
基金资助:
江苏省卫生计生委2018年度医学科研课题(H2018053)

Diagnostic value of multimodal imaging technology with ultrasound shear-wave elastography in metabolisc-associated fatty liver disease

YANG Ru-niu¹, FU Jin², WANG De-qiin³

1. Department of Radiology, Hai'an Hospital, Nantong University, Jiangsu 226600,China;
2. Department of Ultrasound, Hai'an Hospital, Nantong University, Jiangsu 226600, China;
3. Department of Endocrinology, Hai'an Hospital, Nantong University, Jiangsu 226600,China

Received:2022-08-28 Online:2023-09-30 Published:2023-10-24
Contact: YANG Ru-niu,Email:guohongser@163.com

摘要/Abstract

摘要： 目的探讨多模态影像学技术(MIT)联合超声剪切波弹性成像(SWE)对代谢相关性脂肪性肝病(MAFLD)病情程度的评估价值。方法纳入2020年1月至2021年12月收治的疑似MAFLD的患者198例,按照肝活组织检查结果,分为MAFLD组174例和无MAFLD组24例。根据病情程度分为轻度组(61例)、中度组(87例)和重度组(26例),分别采用MIT和SWE检查。观察各组的肝杨氏模量和质子密度脂肪分数(PDFF),Pearson分析肝杨氏模量和PDFF与三酰甘油葡萄糖指数(TyG)的相关性;绘制受试者工作特征曲线(ROC),分析MIT和SWE单独和联合检查对MAFLD评估效能。结果 MAFLD组的肝杨氏模量和PDFF为(5.78±0.56)kPa和(20.33±2.10)%,高于无MAFLD组的(3.27±0.33)kPa和(6.53±0.61)%,差异有统计学意义(t=8.510、13.429,均P<0.05)。重度组的肝杨氏模量和PDFF为(6.34±0.64)kPa和(25.97±2.13)%,分别高于中度和轻度组的(5.59±0.51)kPa、(19.56±1.76)%和(4.98±0.42)kPa、(12.37±1.08)%,差异有统计学意义(F=13.395、19.786,均P<0.05)。MAFLD患者的肝杨氏模量和PDFF与TyG呈正相关(r=0.698、0.724,P<0.01)。MIT和SWE单独及联合检查的AUC分别为 0.801、0.859和0.925,联合检测的敏感度和特异度均高于单独检查(P<0.01)。结论多模态影像学技术联合超声剪切波弹性成像对代谢相关性脂肪性肝病病情程度的诊断价值较高。

Abstract: Objective To investigate the severity of metabolic-associated fatty liver disease (MAFLD) using multimodal imaging technology (MIT) in conjunction with ultrasonic shear-wave elastography (SWE).Methods From January 2020 to December 2021, 198 patients suspected of having MAFLD were studied. They were categorized based on liver pathology biopsy results into an MAFLD group (observation group, n=174) and a NON-MAFLD group (control group, n=24). The observation group was further classified by disease severity into mild(n=61), moderate(n=87), and severe (n=26) subgroups. Both MIT and SWE were performed on these subgroups. Liver Young′s modulus and proton density fat fraction (PDFF) were observed across all groups. Pearson analysis was conducted to determine the correlation between zthe liver Young′s modulus, PDFF and the triacylglycerol glucose index (TyG) . Additionally, the receiver operating characteristic curve (ROC) was utilized to assess the efficacy of both MIT and SWE, individually and combined, in evaluating MAFLD. Results In the observation group, the liver Young′s modulus was 5.78± 0.56 kpa and the PDFF was 20.33±2.10%. Both values were siginidicantly higher than in the control group, where they were 3.27± 0.33 kpa and 6.53±0.61%, respectively (t=8.510 and 13.429, both P<0.05). Within the severe subgroup, the liver Young′s modulus and PDFF were 6.34±0.64 kPa and 25.97±2.13%, respectively, surpassing the figures of the moderate and mild subgroups (5.59±0.51 kPa, 19.56±1.76% and 4.98±0.42 kPa, 12.37±1.08%, respectively). These differences also held statistically significant (F=13.395, 19.786, all P<0.05). A postive correlation was found between the Liver Young′s modulus, PDFF and TyG in patients with MAFLD (P<0.01). ROC analyses revealed AUC values of 0.801, 0.859 and 0.925 for MIT. SWE, and their combined tests, respectively. The combined tests` sensitivity and specificity exceeded those of the SWE alone (P<0.01). Conclusion Multimodal imaging in conjunction with ultrasound shear-wave elastography demonstrateds significant diagnostic value in the assessment of MAFLD.

Key words: MAFLD, MIT, SWE, Pregnancy outcomes

杨孺牛, 符进, 王德琴. 多模态影像技术联合超声剪切波弹性成像对代谢相关性脂肪性肝病的诊断价值[J]. 肝脏, 2023, 28(9): 1101-1104.

YANG Ru-niu, FU Jin, WANG De-qiin. Diagnostic value of multimodal imaging technology with ultrasound shear-wave elastography in metabolisc-associated fatty liver disease[J]. Chinese Hepatolgy, 2023, 28(9): 1101-1104.

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