AFP阴性肝癌相关血清学标志物的研究进展

摘要/Abstract

摘要： 原发性肝癌是临床最常见的恶性肿瘤之一,因发病隐匿进展迅速,通常预后很差。临床最常用于诊断肝癌的血清标志物是甲胎蛋白(AFP),但有部分肝癌患者AFP不升高,其在肝癌的早期筛查中具有灵敏度较低、特异度差等局限性,特别是对于小肝癌的诊断。鉴于AFP的阳性率和特异度有限,其他肝癌标志物的研究有重要意义。因此,本文将对可用于诊断AFP阴性肝癌的血清学标志物做统一简要综述,以期找到更灵敏、更具特异性的替代指标,从而提高早期肝癌的诊断率。

关键词: 肝癌, 诊断, AFP阴性, 血清标志物, 影像学

张瑶瑶, 雷芯, 戴光荣. AFP阴性肝癌相关血清学标志物的研究进展[J]. 肝脏, 2023, 28(9): 1112-1115.

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