DCR3、CRP/Alb、Trx与细菌性肝脓肿并发感染性休克的相关性

肝脏 ›› 2023, Vol. 28 ›› Issue (10): 1227-1230.

DCR3、CRP/Alb、Trx与细菌性肝脓肿并发感染性休克的相关性

谷丽华, 贺晶晶, 袁佳健, 司徒夏昊, 张雯静, 赵霞

200071 上海上海中医药大学附属市中医医院

收稿日期:2023-02-10 出版日期:2023-10-31 发布日期:2023-12-06
通讯作者: 贺晶晶,Email:JOJO8036@163.com
基金资助:
上海市卫生健康委员会科研项目(2022CX007)

Associations between DCR3, CRP/Alb, Trx and infectous shock in pyogenic liver abscess

GU Li-hua, HE Jing-jing, YUan Jia-jian, SITU Xia-hao, ZHANG Wen-jing, ZHAO Xia

Shanghai Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China

Received:2023-02-10 Online:2023-10-31 Published:2023-12-06
Contact: HE Jing-jing,Email:JOJO8036@163.com

摘要/Abstract

摘要： 目的观察细菌性肝脓肿患者诱骗受体3(DCR3)、C反应蛋白/白蛋白(CRP/Alb)、硫氧还蛋白(Trx)与细菌性肝脓肿并发感染性休克相关性。方法选取2019年1月至2021年12月上海市中医医院细菌性肝脓肿患者100例。入院时检测患者DCR3、CRP/Alb、Trx表达,根据1周内患者是否发生感染性休克分为发生组与未发生组,对比两组临床资料及实验室指标,并分析DCR3、CRP/Alb、Trx与细菌性肝脓肿患者并发感染性休克的相关性。结果 100例细菌性肝脓肿患者中发生感染性休克21例(21.00%)。发生组DCR3(3.81±1.08)ng/mL、CRP(109.64±24.96)mg/L、CRP/Alb(3.37±1.02)、Trx(31.42±6.36)ng/mL,高于未发生组(2.96±0.92)ng/mL、(76.49±18.28)mg/L、(2.49±0.81)、(26.14±5.93)ng/mL(t=3.626、6.115、4.182、3.572,P<0.05)。经logistic回归分析结果显示,DCR3、CRP/Alb、Trx可能是细菌性肝脓肿患者并发感染性休克的危险因素(OR=3.425、2.794、1.137,P<0.05);相关性分析显示,DCR3、CRP/Alb、Trx与细菌性肝脓肿并发症感染性休克呈正相关(r=0.342、0.391、0.340,P<0.05)。DCR3、CRP/Alb、Trx预测细菌性肝脓肿并发感染性休克的AUC=0.713、0.740、0.719,具有一定预测价值。结论细菌性肝脓肿患者DCR3、CRP/Alb、Trx与感染性休克的发生密切相关,可用于预测评估患者感染性休克发生状况。

关键词: 细菌性肝脓肿, 感染性休克, 诱骗受体3, C反应蛋白/白蛋白, 硫氧还蛋白

Abstract: Objective To investigate the correlation between inducible Decoy Receptor 3 (DCR3), the C-reactive protein to albumin ratio (CRP/Alb), and thioredoxin (Trx) in patients with pyogenic liver abscess, especially in those with concurrent infectious shock. Methods From January 2019 to December 2021,,100 patients with pyogenic liver abscess admitted to the hospital were prospectively selected for our study, and the expression levels of DCR3, CRP/Alb, and Trx in all patients were assessed. Based on the presenece or absence of infectous shock within 1 week of admission, patients were categorized into either the ‘occurrence group’ or the ‘non-occurrence group’. The clinical data and laboratory indices between these two groups were compared. Finally, the correlation between DCR3, CRP/Alb, Trx and the incidence of infectious shock in these patients was analyzed. Results Out of 100 patients with pyogenic liver abscess, 21(21%) experienced infectious shock.. The levels of DCR3, CRP, CRP/Alb, and Trx were notably higher in the occurred group compared to the non-occurred group (t=3.626、6.115、4.182、3.572,P<0.05); Logistic regression analysis indicated that DCR3, CRP/Alb and Trx could be potential risk factors for infectious shock complications in patients with pyogenic liver abscess (OR=3.425、2.794、1.137, P<0.05). Through point biserial correlation analysis, DCR3, CRP/Alb, and Trx demonstrated a positive correlation with infectious shock arsing from pyogenic liver abscess(r=0.342、0.391、0.340, P<0.05). Furthermore, the ROC curve showed that DCR3, CRP / Alb, and Trx had predicted AUC values of 0.713,0.740, and 0.719 for septic shock, indicating their potential as predictive value. Conclusion DCR3, CRP/Alb, and Trx are strongly associated with the onset of infectious shock in patients with pyogenic liver abscess. They can be utiilized to predict and assess the likelihood of infectious shock in such patients.

Key words: Pyogenic liver abscess, Infectious shock, Decoy Receptor3, C-reactive protein/albumin, Thioredoxin

谷丽华, 贺晶晶, 袁佳健, 司徒夏昊, 张雯静, 赵霞. DCR3、CRP/Alb、Trx与细菌性肝脓肿并发感染性休克的相关性[J]. 肝脏, 2023, 28(10): 1227-1230.

GU Li-hua, HE Jing-jing, YUan Jia-jian, SITU Xia-hao, ZHANG Wen-jing, ZHAO Xia. Associations between DCR3, CRP/Alb, Trx and infectous shock in pyogenic liver abscess[J]. Chinese Hepatolgy, 2023, 28(10): 1227-1230.

参考文献

[1] Khan M Z,Tahir D,Kichloo A,et al.Pyogenic liver abscess and sepsis caused by streptococcus constellatus in the immunocompetent host[J].Case Reports,2020,12(8):e9802.
[2] Lou X,Hou Y,Hui C,et al.Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis[J].Oncol lett,2018,16(1):1147-1154.
[3] 何峰,郜玉峰,王翔,等.GGT/Alb比值对慢性HBV感染者肝纤维化的无创诊断价值[J].临床肝胆病杂志,2021,37(6):1309-1313.
[4] Nishida K,Watanabe H,Murata R,et al.Recombinant long-acting thioredoxin ameliorates AKI to CKD transition via modulating renal oxidative stress and inflammation.[J].Int J mol sci,2021,22(11):5600.
[5] 陈孝平,汪建平,赵继宗.外科学(第9版)[M].北京:人民卫生出版社,2018:414-416.
[6] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中华糖尿病杂志,2018,10(1):4-67.
[7] 中国高血压基层管理指南修订委员会.中国高血压基层管理指南(2014年修订版)[J].中华高血压杂志,2015,23(1):24-43.
[8] 中华医学会儿科学分会急救学组,中华医学会急诊医学分会儿科学组,中国医师协会儿童重症医师分会.儿童脓毒性休克(感染性休克)诊治专家共识(2015版)[J].中华实用儿科临床杂志,2015,30(22):1687-1691.
[9] Fujimori K,Tarasawa K,Fushimi K.Effects of polymyxin B hemoperfusion on septic shock patients requiring noradrenaline: analysis of a nationwide administrative database in Japan[J].Observational Study,2021,50(4-5):560-565.
[10] Merdji H,Kassem M,Chomel L,et al.Septic shock as a trigger of arterial stress-induced premature senescence: a new pathway involved in the post sepsis long-term cardiovascular complications.[J].Vascul pharmacol,2021,19(141):106922.
[11] 张玉达,彭亮,赵静静.过表达DcR3对肝癌细胞自噬功能的影响[J].检验医学与临床,2021,18(22):3254-3256,3260.
[12] Chobrutskiy BI,Chobrutskiy A,Zaman S,et al.High-throughput, sliding-window algorithm for assessing chemical complementarity between immune receptor CDR3 domains and cancer mutant peptides: TRG-PIK3CA interactions and breast cancer[J].Mol Immunol,2021,42(135):247-253.
[13] Cao L,Yang B,Zhang H,et al.DCR3,a new biomarker for sepsis,correlates with infection severity and procalcitonin[J].Oncotarget,2018,9(13):10934-10944.
[14] 段亚楠,秦妮,米婷.高水平血清诱骗受体3预示脓毒症休克患者病情严重[J].内科急危重症杂志,2021,27(4):307-309.
[15] Serbée MJV,Dulfer EA,Dirkx KKT,et al.C-reactive protein to rule out complicated pneumococcal disease manifestations; a retrospective cohort study in adults with pneumococcal bacteraemia[J].Int J Infect Dis,2021,25(111):172-178.
[16] Yang G,Wang D,Phua S,et al.Albumin-based therapeutics capable of glutathione consumption and hydrogen peroxide generation for synergetic chemodynamic and chemotherapy of cancer[J].ACS nano,2022,16(2):2319-2329.
[17] Nishida K,Watanabe H,Miyahisa M,et al.Systemic and sustained thioredoxin analogue prevents acute kidney injury and its-associated distant organ damage in renal ischemia reperfusion injury mice[J].Sci Rep,2020,10(1):20635.
[18] 罗方接,邓景阳,张代龙,等.血清硫氧还蛋白1对颅脑损伤患者预后的预测价值研究[J].临床和实验医学杂志,2020,19(23):2511-2513.
[19] 杨静云,周变华,王国永,等.硫氧还蛋白系统与病原体生物学功能的关系[J].动物医学进展,2021,42(10):105-108.