线粒体自噬调节肝纤维化的研究进展

摘要/Abstract

摘要： 肝纤维化(LF)是由多种慢性肝损伤导致,并以细胞外基质大量沉积以及肝脏正常结构和功能被破坏为特征的病理状态,LF持续进展将导致肝硬化和肝癌。肝细胞富含线粒体,线粒体在氧化供能、脂质代谢、维持细胞稳态、调控细胞死亡中具有重要作用。线粒体自噬是清除受损线粒体、维持细胞内稳态、避免细胞死亡、改变细胞命运的重要细胞进程,该过程在LF中广泛存在。线粒体自噬可能对LF具有促进和抑制的双向调节作用,本文就线粒体自噬与LF的关系及中医药调节线粒体自噬干预LF的研究进展进行综述。

曾小晏, 曾子键, 张子欣, 李晖. 线粒体自噬调节肝纤维化的研究进展[J]. 肝脏, 2024, 29(11): 1315-1318.

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