糖酵解在肝脏疾病中的作用与分子机制的研究进展

摘要/Abstract

摘要： 糖酵解是正常细胞在厌氧或缺氧条件下将葡萄糖或糖原分解成乳酸,同时产生少量ATP。然而,在癌症中,为满足细胞快速增殖的能量需求,即使在有氧条件下,肿瘤细胞也会更倾向于通过糖酵解将葡萄糖分解成乳酸,而不是氧化磷酸化,称为Warburg效应。因此,发现在肝细胞癌(hepatocellular carcinoma,HCC)中过度激活的糖酵解的酶,可以为HCC的治疗提供新的思路。近年来,越来越多研究发现在不同肝脏疾病中糖酵解不同程度的增强。本文主要阐述近年来糖酵解在肝脏疾病中的研究进展,为治疗肝脏疾病提供新思路。

张小雅, 石春霞, 龚作炯. 糖酵解在肝脏疾病中的作用与分子机制的研究进展[J]. 肝脏, 2024, 29(11): 1312-1314.

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