超声定量评估及GGT/PLT在乙型肝炎肝纤维化中的应用

摘要/Abstract

摘要： 目的分析超声定量评估及γ-谷氨酰基转移酶(GGT)/血小板计数(PLT)在乙型肝炎肝纤维化中的应用价值。方法回顾性分析2021年1月至2024年1月在我院进行治疗的108例乙型肝炎肝纤维化患者的临床资料,依据患者肝纤维化程度进行分组,分别分为S1期组(n=28),S2期组(n=30),S3期组(n=28),S4期组(n=22)。比较各组超声定量参数和血清检查结果,采用斯皮尔曼(Spearman)秩相关分析乙型肝炎肝纤维化患者超声定量参数、血清检查结果的相关性。结果 S4期组超声定量参数高于S1、S2、S3期患者,S3期组超声定量参数高于S1、S2期患者,S2期组超声定量参数高于S1期患者(F=95.866、76.567、36.158、25.092,P＜0.05);S4期组GGT、GGT/PLT高于S1、S2、S3期患者,PLT低于S1、S2、S3期患者,S3期组GGT、GGT/PLT高于S1、S2期患者,PLT低于S1、S2期患者,S2期组GGT、GGT/PLT高于S1期患者,PLT低于S1期患者(F=265.225、352.658、222.817,P＜0.05)。相关性分析显示,乙型肝炎肝纤维化患者超声定量参数与血清GGT、GGT/PLT水平呈正相关,与PLT水平呈负相关(P＜0.05)。结论超声定量评估、GGT/PLT与乙型肝炎肝纤维化程度关系密切,临床诊治时可结合以上指标进一步判断患者病情严重程度。

关键词: 超声定量评估, γ-谷氨酰基转移酶, 血小板计数, 乙型肝炎, 肝纤维化

Abstract: Objective To analyze the application value of quantitative ultrasound and gamma glutamyltransferase (GGT)/platelet count (PLT) ratio in the evaluation of liver fibrosis in hepatitis B patients. Methods The clinical data of 108 patients with hepatitis B and liver fibrosis treated from January 2021 to January 2024 were retrospectively analyzed. Based on the degree of liver fibrosis, the patients were divided into S1 stage group (n=28), S2 stage group (n=30), S3 stage group (n=28), and S4 stage group (n=22). The quantitative ultrasound parameters and serum test results of each group were compared. Spearman rank correlation analysis was used to examine the correlation between quantitative ultrasound parameters and serum test results in hepatitis B patients with liver fibrosis. Results The quantitative ultrasound parameters of the patients in S4 stage group were higher than those in S1, S2, and S3 stage groups. The quantitative ultrasound parameters of the patients in S3 stage group were higher than those in S1 and S2 stage groups, and the quantitative ultrasound parameters of the patients in S2 stage group were higher than those in S1 stage group (F=95.866, 76.567, 36.158, 25.092, P<0.05). The GGT level and GGT/PLT ratio of the patients in S4 stage group were higher, whereas PLT level was lower than those in S1, S2, and S3 stage groups. The GGT level and GGT/PLT ratio of patients in S3 stage group were higher, whereas the PLT level was lower than those in S1 and S2 stage groups. The GGT level and GGT/PLT ratio of patients in S2 stage group was higher than that of patients in S1 stage group (F=265.225, 352.658, 222.817, P<0.05). The result of corelation analysis showed that ultrasound quantitative parameters in patients with hepatitis B and liver fibrosis were positively correlated with serum GGT level and GGT/PLT ratio, and negatively correlated with PLT level (P<0.05). Conclusion The quantitative evaluation of ultrasound, GGT/PLT ratio, and the degree of liver fibrosis in hepatitis B patients are closely related. In clinical diagnosis and treatment, the above indicators can be combined to evaluate the severity of the patients’ condition.

Key words: Ultrasonic quantitative evaluation, Gamma-glutamyltransferase, Platelet count, Hepatitis B, Hepatic fibrosis

万品凤, 周恕敏, 方群, 李娜. 超声定量评估及GGT/PLT在乙型肝炎肝纤维化中的应用[J]. 肝脏, 2025, 30(8): 1076-1079.

WAN Pin-feng, ZHOU Shu-min, FANG Qun, LI Na. The application of quantitative ultrasound and GGT/PLT ratio in the evaluation of liver fibrosis in hepatitis B patients[J]. Chinese Hepatolgy, 2025, 30(8): 1076-1079.

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