慢加急性肝衰竭预后评分系统的研究进展   姜慧杰 蒋雪梅

摘要/Abstract

摘要： 慢加急性肝衰竭(ACLF)因其病情变化急剧、短期病死率高,在临床上受到广泛关注。鉴于ACLF患者对内科综合治疗普遍反应欠佳,诊疗过程中早期且准确的预后评估,对于临床治疗决策具有重要意义。本文通过回顾近年来在临床上广泛应用的ACLF预后评分系统,包括Child-Turcotte-Pugh(CTP)评分、终末期肝病模型(MELD)及其衍生评分、慢性肝衰竭联盟-序贯器官衰竭评估(CLIF-SOFA)及其衍生评分、北美终末期肝病研究联盟-ACLF(NACSELD-ACLF)评分、亚太肝病学会ACLF研究联盟-ACLF(AARC-ACLF)评分、中国重症乙型肝炎研究学组-ACLF(COSSH-ACLF)评分及其衍生评分等,阐述各评分系统的特点、优势和局限性,旨在为临床医生早期、准确地评估ACLF患者预后提供参考,并对未来ACLF预后评分系统的研究和开发进行展望。

关键词: 慢加急性肝衰竭, 预后, 模型, 综述

姜慧杰, 蒋雪梅. 慢加急性肝衰竭预后评分系统的研究进展姜慧杰蒋雪梅[J]. 肝脏, 2025, 30(8): 1160-1165.

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