剪切波弹性成像参数及肝癌患者肿瘤标志物水平与病灶组织资料的关联度分析

摘要/Abstract

摘要： 目的探索剪切波弹性成像(SWE)参数及肝癌患者的肿瘤标志物水平与病灶组织特征之间的相关性。方法将2020年6月至2023年6月我院诊治的93例肝癌患者作为研究对象纳入肝癌组,将同期住院治疗的50例肝结节患者纳入结节组。通过剪切波弹性成像测量两组患者的LSM、Vmax、Vmean等弹性参数,采用ELISA法检测血清AFP、GGT、CEA水平,分析剪切波弹性成像参数及肝癌患者肿瘤标志物水平与病灶组织资料的相关性。结果肝癌组与结节组的肝功能分级、肝纤维分级、肝脏炎症活动度比较差异具有统计学意义(P<0.05)。肝癌组血清AFP水平为(245.68±82.43)μg/L,GGT为(257.55±95.72)U/L,CEA为(18.22±4.67)U/L,均显著高于结节组[分别为(9.15±2.72)μg/L、(16.24±5.43)U/L、(0.91±0.24)U/L,P<0.05]。肝癌组在SWE参数上,LSM值为(33.47±2.68)kPa,Vmax为(3.92±0.57)m/s,Vmean为(3.47±0.35)m/s,显著高于结节组[分别为(15.87±1.23)kPa、(2.61±0.24)m/s、(2.36±0.22)m/s,P<0.05]。采用Spearman相关性分析发现,肝功能分级、肝纤维分级、肝脏炎症活动度与AFP、GGT、CEA、LSM、Vmax、Vmean存在正相关(均P<0.05)。结论剪切波弹性成像参数及肝癌患者肿瘤标志物水平与病灶组织特征的相关性分析显示,SWE参数及血清AFP、GGT、CEA水平可以作为评估肝癌病情的有效工具。

关键词: 剪切波弹性成像, 肝癌, 肿瘤标志物, 病灶组织, 相关性

Abstract: Objective To investigate the correlation between shear wave elastography (SWE) parameters and tumor marker levels with lesion tissue characteristics in liver cancer patients. Methods 93 liver cancer patients in our hospital between June 2020 and June 2023 were recruited into the study as the liver cancer group, and 50 patients with liver nodules were included in the nodule group for comparison. SWE was utilized to measure elasticity parameters such as liver stiffness measurement (LSM), maximum velocity (Vmax), and mean velocity (Vmean). Serum levels of alpha-fetoprotein (AFP), gamma-glutamyl transferase (GGT), and carcinoembryonic antigen (CEA) were determined using enzyme-linked immunosorbent assay (ELISA), and the relationship between these SWE parameters and tumor marker levels with lesion tissue characteristics was analyzed. Results Significant differences were observed between the liver cancer and nodule groups in terms of liver function grading, liver fibrosis grading, and liver inflammation activity (P<0.05). Serum levels of AFP, GGT, and CEA were (245.68 ± 82.43) μg/L, (257.55 ± 95.72) U/L, and (18.22 ± 4.67) U/L, respectively, all of which were significantly higher than in the nodule group [(9.15±2.72) μg/L, (16.24±5.43) U/L, and (0.91±0.24) U/L, respectively; P<0.05]. In the liver cancer group, LSM was (33.47±2.68) kPa, Vmax was (3.92±0.57) m/s, and Vmean was (3.47±0.35) m/s, which were significantly higher than those in the nodule group [(15.87±1.23) kPa, (2.61±0.24) m/s, and (2.36±0.22) m/s, respectively; P<0.05]. Spearman correlation analysis indicated that liver function grading, liver fibrosis grading, and liver inflammation activity were positively correlated with the levels of AFP, GGT, CEA, LSM, Vmax, and Vmean (P<0.05 for all). Conclusion The analysis of the correlation between SWE parameters and tumor marker levels with lesion tissue characteristics in liver cancer patients demonstrates that SWE parameters along with serum AFP, GGT, and CEA levels can serve as effective tools for assessing the condition of liver cancer.

Key words: Shear wave elastography, Liver cancer, Tumor markers, Lesion tissue, Correlation

刘苗, 张群青, 吴娟. 剪切波弹性成像参数及肝癌患者肿瘤标志物水平与病灶组织资料的关联度分析[J]. 肝脏, 2025, 30(9): 1234-1237.

LIU Miao, ZHANG Qun-qing, WU Juan. Analysis of the correlation between shear wave elastography parameters and tumor marker levels with lesion tissue characteristics in liver cancer patients[J]. Chinese Hepatolgy, 2025, 30(9): 1234-1237.

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