丁型肝炎病毒的流行病学、临床特征与治疗进展

摘要/Abstract

摘要： 丁型肝炎病毒(HDV)为乙型肝炎病毒(HBV)依赖性病原体,是加重HBV相关肝病的重要因素。全球约4.5%的乙型肝炎表面抗原携带者合并HDV感染,其发生肝硬化、肝功能失代偿和肝细胞癌的风险显著高于单纯HBV感染者。多国队列研究进一步提示,HDV感染不仅与肝病进展密切相关,还显著增加全因死亡率及肝病相关死亡率。然而,现有研究在流行病学差异、临床结局和筛查策略等方面仍存在局限。聚乙二醇干扰素治疗疗效有限且不良反应明显,新药bulevirtide的临床应用或可为患者带来新的治疗选择。本文结合最新研究进展,综述HDV的流行病学特征、临床结局、筛查策略与治疗进展,为未来防控与诊疗优化提供参考。

关键词: 丁型肝炎病毒, 乙型肝炎病毒, 肝硬化, 肝细胞癌, Bulevirtide

王文静, 王艳. 丁型肝炎病毒的流行病学、临床特征与治疗进展[J]. 肝脏, 2025, 30(10): 1309-1311.

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