单中心脂肪性肝病的危险因素分析

肝脏 ›› 2026, Vol. 31 ›› Issue (4): 565-568.

单中心脂肪性肝病的危险因素分析

邓飞蝶, 王光福, 杨扬, 王子明

550002 贵阳贵州中医药大学第一临床医学院(邓飞蝶);
550001 贵阳贵州中医药大学第一附属医院体检中心(王光福,杨扬),肛肠科二病区(王子明)

收稿日期:2025-07-29 出版日期:2026-04-30 发布日期:2026-06-04
通讯作者: 王子明,Email:83511814@qq.com

Analysis of risk factors for fatty liver disease in a single-center study

DENG Fei-die¹, WANG Guang-fu², YANG Yang², WANG Zi-ming³

1. First Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China;
2. Physical Examination Center, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China;
3. Second Ward of Anorectal Department, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China

Received:2025-07-29 Online:2026-04-30 Published:2026-06-04
Contact: WANG Zi-ming,Email:83511814@qq.com

摘要/Abstract

摘要： 目的探讨脂肪性肝病的流行病学特征及危险因素。方法纳入2024年1月至2024年12月贵州中医药大学第一附属医院体检者18 921名,根据影像学检查结果分为脂肪肝组(n=5 083)及非脂肪肝组(n=13 838)。比较两组的临床基线资料、实验室检查结果、辅助检查结果,使用二元logistic回归分析评估罹患脂肪肝的危险因素。结果脂肪肝检出率方面,女性2 728例(53.67%),高于男性2 355例(46.33%)。脂肪肝组与非脂肪肝组比较发现, TG、HDL-C、WBC、RBC、PLT、ALC、AMC、TyG、SIRI、AISI差异有统计学意义(P<0.05)。二元logistic回归分析发现,TyG(OR=1.07,95%CI:1.02~1.122,P<0.001)、AISI(OR=1.003,95%CI:1.002~1.004,P<0.001)是脂肪肝发病的独立危险因素。SII(OR=0.998,95%CI:0.998~0.999);SIRI(OR=0.618,95%CI:0.525~0.727)是保护因素。TyG每增加1个数值,脂肪肝检出率高7.0%。AISI每增加1个数值,脂肪肝检出率高0.3%。结论 TyG、AISI是脂肪肝发生的危险因素,而SII、SIRI是保护因素。

关键词: 脂肪肝, TyG, AISI, SII, SIRI

Abstract: Objective To investigate the epidemiological characteristics and risk factors of fatty liver disease(FLD) using cross-sectional data. Methods A total of 18 921 examinees at the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from January 2024 to December 2024 were enrolled. Participants were divided into a FLD group (n=5 083) and a non-FLD group (n=13 838) based on imaging findings. Clinical baseline data, laboratory results, and auxiliary examination results were collected and analyzed. Logistic regression was used to identify risk factors for fatty liver disease. Results The detection rate of FLD was 26.86%, with a higher prevalence in females (n=2 728, 27.24%) than males (n=2 355, 26.45%). Compared to the non-FLD group, the FLD group showed statistically significant differences (P<0.05) in TG, HDL-C, WBC, RBC, PLT, ALC, AMC, TyG, SIRI and AISI. Binary logistic regression analysis identified TyG (OR=1.07,95%CI:1.02~1.122,P<0.001) and AISI (OR=1.003,95%CI:1.002~1.004,P<0.001) as independent risk factors for FLD. Conversely, systemic immune-inflammation index SII (OR=0.998,95%CI:0.998~0.999) and SIRI (OR=0.618,95%CI:0.525~0.727) were protective factors. For every 1-unit increase in TyG, the detection rate of fatty liver increases by 7.0%. For every 1-unit increase in AISI, the detection rate of fatty liver increases by 0.3%. Conclusion TyG and AISI are risk factors for the development of fatty liver, while SII and SIRI are protective factors.

Key words: Fatty liver disease, TyG, AISI, SII, SIRI

邓飞蝶, 王光福, 杨扬, 王子明. 单中心脂肪性肝病的危险因素分析[J]. 肝脏, 2026, 31(4): 565-568.

DENG Fei-die, WANG Guang-fu, YANG Yang, WANG Zi-ming. Analysis of risk factors for fatty liver disease in a single-center study[J]. Chinese Hepatolgy, 2026, 31(4): 565-568.

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