SHP2在非酒精性脂肪性肝病中的研究进展

摘要/Abstract

摘要： 非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)发病率逐年上升,与肥胖、2型糖尿病和心血管疾病密切相关,已成为亟需解决的临床疾病。Src同源性2结构域的蛋白酪氨酸磷酸酶(Src homology-2 domain-containing PTP2, SHP2)是一种重要的非受体型酪氨酸磷酸酶,在胰岛素抵抗、脂质代谢、炎症反应、肝纤维化等中的作用逐渐被发现和重视,本文就SHP2在NAFLD发生、发展过程中的作用,以及SHP2对NAFLD的治疗作用进行综述,为临床治疗NAFLD提供新思路。

梁倩, 焦文, 唐宽银, 王慧. SHP2在非酒精性脂肪性肝病中的研究进展[J]. 肝脏, 2026, 31(4): 591-594.

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