精氨酸谷氨酸注射液对肝切除术后缺血再灌注损伤的保护作用及安全性

肝脏 ›› 2018, Vol. 23 ›› Issue (11): 1002-1004.

精氨酸谷氨酸注射液对肝切除术后缺血再灌注损伤的保护作用及安全性

李锡锋, 施乐华, 汪宇, 王文超, 张小峰

200000 上海第二军医大学附属东方肝胆外科医院肝胆外科

收稿日期:2018-07-11 出版日期:2018-11-30 发布日期:2020-04-28
通讯作者: 张小峰,Email:zxf_ehbh@126.com

Received:2018-07-11 Online:2018-11-30 Published:2020-04-28

摘要/Abstract

摘要： 目的研究精氨酸谷氨酸注射液对肝切除术后缺血再灌注损伤的保护作用及安全性。方法选择2015年3月至2017年3于上海东方肝胆外科医院行择期肝部分切除患者93例,随机分为对照组和观察组,对照组46例、观察组47例。对照组予以常规保肝药,观察组予以精氨酸谷氨酸注射液治疗,比较两组黄嘌呤氧化酶(XOD)、热休克蛋白(HSP)、中性粒细胞、一氧化氮(NO)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血氨、T细胞亚群及不良反应发生情况。结果治疗后,观察组患者XOD、HSP、中性粒细胞下降趋势明显高于对照组(P<0.05),观察组NO上升趋势优于对照组(P<0.05);治疗后观察组患者AST、ALT及血氨下降程度均高于对照组(P<0.05);治疗后,观察组T细胞亚群CD3⁺、CD4⁺、CD4⁺/CD8⁺下降幅度均高于对照组(P<0.05),CD8⁺上升幅度高于对照组(P<0.05);两组患者治疗期间的不良反应发生情况比较差异无统计学意义(P>0.05)。结论精氨酸谷氨酸注射液能够减轻肝部分切除术后缺血再灌注损伤,保护肝功能,可能与其能够提高机体对氧自由基清除能力,抑制过氧化反应,改善机体免疫功能有关。

关键词: 肝部分切除术, 精氨酸谷氨酸注射液, 缺血再灌注损伤, 保护作用, 安全性

李锡锋, 施乐华, 汪宇, 王文超, 张小峰. 精氨酸谷氨酸注射液对肝切除术后缺血再灌注损伤的保护作用及安全性[J]. 肝脏, 2018, 23(11): 1002-1004.

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