关键词: 药物性肝炎, 自身免疫性抗体, 阳性检出率, 临床分析

Abstract: Objective To investigate the clinical significance of autoimmune antibody (AA) detection in the differential diagnosis of drug-induced liver injury (DILI), and its positive rate among different patients of DILI.Methods Clinical data of patients with primary diagnosis of DILI, including age, gender, disease onset time, AA, liver function index, varieties of hepatotoxic drugs, was collected for correlation analysis with AA positive rate.Results There were no differences in AA positive rate among different clinical types in respect of gender, age, liver injury type and Child score , and so on. However, AA positive rate showed positive correlation with Child score. Patients with medication time ≥ 30 days had significantly higher positive rate of AA than those with medication time < 30 days.Conclusion For DILI patients, the positive rate of AA had a positive correlation with the medication time, which suggested that AA detection might have significant referential value for abnormal liver function patients with prolong medication, but not differential diagnosis of western or Chinese drugs-induced liver injury.

Key words: Drug-induced liver injury, Autoimmune antibody, Positive rate, Clinical analysis