乙型肝炎肝硬化并发原发性肝癌相关危险因素Meta分析

摘要/Abstract

摘要： 目的综合评价中国乙型肝炎肝硬化人群并发原发性肝癌的相关危险因素。方法计算机检索英文数据库PubMed、EBSCO、Highwire、Web of Science及中文数据库中国知网(CNKI)、万方数据库、维普期刊资源整合服务平台(VIP)中2005至2018年与乙型肝炎肝硬化并发原发性肝癌相关因素有关的研究或分析,同时手工检索相关资料。严格按照纳入和排除标准对所获文献进行筛选、提取资料和质量评价,完成后应用Stata 14.0进行Meta分析。结果最终纳入文献共12篇,其中中文文献11篇,英文文献1篇;纳入人群总数2 313例,病例组1 171例,对照组1 142例。Meta分析显示,乙型肝炎肝硬化患者的性别、饮酒史、吸烟史、肝癌家族史、糖尿病病史、不良饮食习惯、未经抗病毒治疗以及HBV DNA水平、HBsAg阳性、HBeAg阳性、抗-HBe阳性与乙型肝炎肝硬化并发原发性肝癌有关,各因素分析合并OR值及其各自95%CI值分别为1.30[1.03~1.65]、2.82[1.86~4.29]、2.98[1.62~5.48]、4.36[2.54~7.49]、2.79[2.04~3.82]、2.39[1.58~3.62]、3.74[2.86~4.87]、3.93[2.65~5.83]、5.52[3.61~8.43]、4.18[3.08~5.66]、2.59[1.91~3.53]。结论性别、饮酒史、吸烟史、肝癌家族史、糖尿病病史、不良饮食习惯、未经抗病毒治疗以及HBV DNA水平、HBsAg阳性、HBeAg阳性、抗-HBe阳性是导致乙型肝炎肝硬化患者并发肝癌的危险因素。

关键词: 乙肝, 肝硬化, 原发性肝癌, 危险因素, 病例对照, Meta分析

陈曦阳光, 吴君. 乙型肝炎肝硬化并发原发性肝癌相关危险因素Meta分析[J]. 肝脏, 2019, 24(4): 398-403.

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