[1] 中华医学会肝病学分会脂肪肝和酒精性肝病学组, 中国医师协会脂肪性肝病专家委员会. 非酒精性脂肪性肝病防治指南(2018更新版). 实用肝脏病杂志,2018, 21:177-186. [2] Cho S, Yoon JY. Organ-on-a-chip for assessing environmental toxicants. Curr Opin Biotechnol,2017,45:34-42. [3] Xiang C, Du Y, Meng G, et al. Long-term functional maintenance of primary human hepatocytes in vitro. Science,2019,364:399-402. [4] Hassan S, Sebastian S, Maharjan S, et al. Liver-on-a-Chip Models of Fatty Liver Disease. Hepatology,2020,71:733-740. [5] Ehrlich A, Duche D, Ouedraogo G, et al. Challenges and Opportunities in the Design of Liver-on-Chip Microdevices. Annu Rev Biomed Eng, 2019,21:219-239. [6] Kozyra M, Johansson I, Nordling ?, et al. Human hepatic 3D spheroids as a model for steatosis and insulin resistance. Sci Rep,2018,8:14297. [7] Zhang YS, Aleman J, Shin SR, et al. Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors. Proc?Natl?Acad?Sci U S A,2017,114:E2293-E2302. [8] Rennert K, Steinborn S, Gr?ger M, et al. A microfluidically perfused three dimensional human liver model. Biomaterials,2015,71:119-131. [9] Weng Y-S, Chang S-F, Shih MC, et al. Scaffold-Free Liver-On-A-Chip with Multiscale Organotypic Cultures. Adv Mater,2017,29:1701545. [10] Amin AB, Jannick T, Jurgita P, et al. Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform. Biofabrication, 2017,9:015014. [11] Domansky K, Inman W, Serdy J, et al. Perfused multiwell plate for 3D liver tissue engineering. Lab Chip,2010,10:51-58. [12] Gori M, Simonelli MC, Giannitelli SM, et al. Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device. PLoS One,2016,11:e0159729. [13] Kostrzewski T, Cornforth T, Snow SA, et al. Three dimensional perfused human in vitro model of non-alcoholic fatty liver disease. World J Gastroenterol, 2017,23:204-215. [14] Lee SY, Sung JH. Gut–liver on a chip toward an in vitro model of hepatic steatosis. Biotechnol Bioengin,2018,115:2817-2827. |