关键词: 乙肝相关性肾病, 乙型肝炎抗原, 肾损伤, 预后

Abstract: Objective To study the relationship between positive expression of tubule hepatitis b antigen (HBAg) and prognosis of hepatitis B virus related renal function injury.Methods The clinical data of 80 patients with hepatitis B related nephropathy (HBV-GN) admitted to our hospital from December 2016 to December 2018 were retrospectively analyzed. According to the presence and absence of HBAg deposition in renal tissues, all patients were divided into the HBAg deposition group and the no-HBAg deposition group, with 40 patients in each group.Compare two groups of patients with basic data and laboratory test results, including gender, age, clinical manifestation, the existence of nephrotic syndrome, nephritis syndrome, kidney damage), hepatitis B surface antigen (HBsAg), hepatitis B virus E antigen (HBeAg), albumin (Alb), low density lipoprotein (LDL), triglycerides (TG), cholesterol (TC), hemoglobin (Hb), blood uric acid (SUA), serum creatinine (Scr), hepatitis B virus DNA (HBV DNA);The differentiated information was incorporated into the multivariate Logistic regression model to identify the risk factors affecting the prognosis of HBV-GN patients. Results In the HBAg deposition group, 32 males, aged (41.54 ± 9.46) years, 24 with nephrotic syndrome, 22 with nephritis syndrome, ALB (54.37 ± 6.43) g/L, LDL (3.84 ± 1.43) mmol/L, TG (1.43 ± 0.84) mmol/L, TC (6.14 ± 1.03) mmol/L, Hb (147.54 ± 20.46) g/L, SUA (382.62 ± 94.57) μmol/L, Scr (133.75 ± 13.76) μmol/L, HBV DNA (5.43 ± 1.42) copies/mL and 30 men without HBAg deposition, aged (41.58 ± 9.53) years, 25 with nephrotic syndrome, 17 with nephritis syndrome, ALB (54.40 ± 6.58) g/L, LDL (3.81 ± 1.38) mmol/L, TG (1.44 ± 0.86) mmol/L, TC (6.11 ± 0.93) mmol/L, Hb (146.87 ± 20.41) g/L, SUA (386.54 ± 96.75) μmol/L, There was no significant difference between Scr (133.70 ± 13.54) μmol/L and HBV DNA (5.57 ± 1.34) copies/mL, P>0.05;Renal function impairment was shown in the HBAg deposition group, and patients with positive serum HBsAg and HBeAg were significantly more than those without the HBAg deposition group. (34 with renal impairment, 35 with HBsAg positive, and 33 with HBeAg positive. Twenty cases were HBsAg positive, 19 cases were HBeAg positive, P<0.05).Multivariate Logistic regression analysis confirmed that there was renal impairment. Positive HBsAg and HBeAg were risk factors affecting the prognosis of patients with HBV-GN, both P<0.05.Conclusion There are many risk factors that affect the prognosis of patients with HBV-GN, such as renal function damage and positive expression of renal tubule HBAg, which should be concerned by clinicians in clinical treatment.

Key words: Hepatitis B related nephropathy;Hepatitis B antigen;Kidney injury;The prognosis