维生素D受体在代谢相关性脂肪性肝病中的作用研究进展

摘要/Abstract

摘要： 目前尚缺少对代谢相关性脂肪性肝病(metabolic associated fatty liver disease, MAFLD)有效的治疗策略。近年来,维生素D受体(Vitamin D receptor, VDR)被认为可作为MAFLD的治疗靶点。但VDR不仅接受维生素D受体激动,也可与胆汁酸等其他配体结合,此外VDR可以由脂肪酸和胰岛素诱导。VDR在肝脏不同细胞中发挥不同作用,在非实质细胞中VDR的激活可改善肝脏炎症、纤维化,但是在肝细胞中VDR激活可以加速脂质蓄积。本文综述了近年来关于VDR激活与MAFLD的关系,及肝脏中VDR表达和激活的影响因素,为今后MAFLD研究提供基础。

关键词: 代谢相关性脂肪性肝病, 维生素D受体, 脂质代谢, 炎症

林慧玲, 陈玲红, 曾清芳. 维生素D受体在代谢相关性脂肪性肝病中的作用研究进展[J]. 肝脏, 2021, 26(12): 1415-1417.

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