96例ALT正常慢性HBV感染者进展影响因素及肝脏病理学分析

肝脏 ›› 2021, Vol. 26 ›› Issue (7): 750-753.

96例ALT正常慢性HBV感染者进展影响因素及肝脏病理学分析

曹欣, 邓浩辉, 肖艳华, 余卫华, 陈燕清

510060 广东广州医科大学附属市八医院

收稿日期:2021-04-27 出版日期:2021-07-31 发布日期:2021-09-02
通讯作者: 邓浩辉,Email:gz8hdhh@126.com
基金资助:
广东省医学科学技术研究基金项目(B2021302)

An analysis of the influencing factors for histological progression in 96 cases of chronic hepatitis B virus-infected patients with normal alanine aminotransferase level

CAO Xin, DENG Hao-hui, XIAO Yan-hua, YU Wei-hua, CHEN Yan-qing

Department of Hepatology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangdong 510060,China

Received:2021-04-27 Online:2021-07-31 Published:2021-09-02
Contact: DENG Hao-hui, Email: gz8hdhh@126.com

摘要/Abstract

摘要： 目的探讨ALT正常慢性HBV感染者发生明显组织学变化的影响因素。方法回顾性分析2018年6月至2020年12月广州医科大学附属市八医院住院并行肝组织穿刺活检术的96例慢性HBV感染者的临床指标,根据肝脏病理结果分为观察组和对照组,两组比较采用t检验和χ²检验,Logistic回归分析出现明显组织学变化(G≥2或S≥2)的影响因素。结果 96例患者中,观察组(G≥2或S≥2)42例(43.8%),对照组(G<1或S<1)54例(56.2%)。单因素分析提示,年龄(P=0.041)、性别(P=0.034)、肝硬化/HCC家族史(P=0.039)、HBeAg定量(P=0.043),是ALT正常慢性HBV感染者肝脏病理出现明显组织学变化(G≥2或S≥2)的独立影响因素(P<0.05)。结论 ALT正常慢性HBV感染者的年龄、性别、肝硬化/HCC家族史、HBeAg定量,是肝脏病理出现明显组织学变化的影响因素,也可作为是否需要启动抗病毒治疗的重要参考因素。

关键词: ALT正常, HBV感染者, 影响因素, 肝脏病理学, 组织学变化

Abstract: Objective To investigate the influencing factors for significant histological pathological progression in chronic hepatitis B virus (HBV) infected patients with normal alanine aminotransferase (ALT) level. Methods The clinical data of 96 patients with chronic HBV infection who were admitted to the hospital and underwent liver biopsies from June 2018 to December 2020 were retrospectively analyzed. They were divided into the observation group and the control group according to their pathological changes. The measurement data between these two groups were analyzed by t-test. The counting data were analyzed by chi square test. The influencing factors for significant histological changes (G≥2 or S≥2) were analyzed by logistic regression. Results Among these 96 patients, 42 cases (43.8%) were in the observation group (G8 2 or S 2) and 54 cases (56.2%) were in the control group (G<1 or S<1). Age(P=0.041),gender (P=0.034),family history of liver cirrhosis/HCC (P=0.039),HBeAg quantitative values (P=0.043) were the independent influencing factors for significant liver pathological changes (G≥2 or Sp2) in patients with normal ALT and chronic HBV infection (P<0.05). Conclusion For chronic HBV infected patients with normal ALT, age,gender,family history of liver cirrhosis/HCC and HBeAg quantitation were the influencing factors for significant changes in liver pathologies in these patients. These factors can also be used as important reference factors for starting antiviral therapy.

Key words: Normal ALT, HBV infection, Influencing factors, Liver pathology, Histological changes

曹欣, 邓浩辉, 肖艳华, 余卫华, 陈燕清. 96例ALT正常慢性HBV感染者进展影响因素及肝脏病理学分析[J]. 肝脏, 2021, 26(7): 750-753.

CAO Xin, DENG Hao-hui, XIAO Yan-hua, YU Wei-hua, CHEN Yan-qing. An analysis of the influencing factors for histological progression in 96 cases of chronic hepatitis B virus-infected patients with normal alanine aminotransferase level[J]. Chinese Hepatolgy, 2021, 26(7): 750-753.

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