脓毒血症肝损伤患者血清TBA、ALP水平与凝血功能特征观察

摘要/Abstract

摘要： 目的观察脓毒血症肝损伤患者血清总胆汁酸(TBA)、碱性磷酸酶(ALP)水平与凝血功能特征。方法选择2018年3月至2021年3月85例脓毒血症合并肝损伤患者作为观察组,另于同期选择脓毒血症无肝功能损伤患者作为对照组。入组当天检测两组血清TBA、ALP、D-二聚体(D-dimer)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)水平。结果观察组TBA、ALP水平分别为(94.37±15.62)μmol/L、(24.59±4.33)U/L,对照组TBA、ALP水平分别为(82.35±13.28)μmol/L,(19.85±3.62)U/L,观察组TBA、ALP水平较对照组高,P<0.05;观察组D-dimer、APTT、PT、FIB水平分别为(3164.25±526.73)μg/mL、(35.28±7.14)s、(15.38±4.92)s、(4.15±0.96)g/L,对照组D-dimer、APTT、PT、FIB水平分别为(1 624.37±328.17)μg/mL、(31.96±5.52)s、(13.84±5.02)s、(3.36±1.18)g/L,观察组D-dimer、APTT、PT、FIB水平较对照组高,P<0.05。结论脓毒血症可导致患者肝功能损伤,引起TBA、ALP水平上升,并可导致凝血功能异常。

关键词: 脓毒血症, 肝损伤, 总胆汁酸, 碱性磷酸酶, 凝血功能

Abstract: Objective To observe the levels of serum total bile acid (TBA), alkaline phosphatase (ALP) and coagulation function in patients with sepsis induced liver injury. Methods From March 2018 to March 2021, 85 sepsis patients with liver injury were selected as the observation group, and patients with sepsis without liver damage were selected as the control group during the same period. On the day of enrollment, the levels of serum TBA, ALP, D-dimer, activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrinogen (FIB) were detected in the two groups. Results The levels of TBA and ALP in the observation group were (94.37±15.62) μmol/L and (24.59±4.33) μmol/L, respectively. The levels of TBA and ALP in the control group were (82.35±13.28) μmol/L and (19.85±3.62) μmol/L, respectively. And the levels of TBA and ALP in the observation group were higher than those in the control group (P<0.05). The levels of D-dimer, APTT, PT and FIB in the observation group were (3164.25±526.73) ng/mL, (35.28±7.14) s, (15.38±4.92) s, and (4.15±0.96) g/L in the control group, respectively. The levels of APTT, PT and FIB were (1624.37±328.17) ng/mL, (31.96±5.52) s, (13.84±5.02) s, (3.36±1.18) g/L, respectively. The levels of D-dimer, APTT, PT, FIB in the observation group were higher than those in the control group (P<0.05). Conclusion Sepsis can lead to liver function damage, increase of TBA and ALP levels, and abnormal coagulation function.

Key words: Sepsis, Liver injury, Total bile acid, Alkaline phosphatase, Coagulation function

王俊峰, 赵亮, 王俊杰, 杨春秋. 脓毒血症肝损伤患者血清TBA、ALP水平与凝血功能特征观察[J]. 肝脏, 2022, 27(5): 593-595.

WANG Jun-feng, ZHAO Liang, WANG Jun-jie, YANG Chun-qiu. The study of serum TBA, ALP and coagulation function in sepsis patients with liver injury[J]. Chinese Hepatolgy, 2022, 27(5): 593-595.

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