关键词: 肝硬化, 肝源性糖尿病, 临床表现, 预后

Abstract: Objective To compare the clinical manifestations and prognosis of liver cirrhosis patients with simple cirrhosis and those with hepatogenic diabetes (HD), to explore the influence of blood glucose level on the prognosis of the disease, and to summarize the experience of treatment and nursing.Methods The clinical data of 82 patients with hepatic cirrhosis from January 2019 to January 2020 were analyzed retrospectively. Within them, patients with simple cirrhosis were grouped as the control group, and patients combined with hepatogenic diabetes (HD) cirrhosis were grouped as the observation group. They were compared with the differences in sex, age of admission, length of hospital-stay, course of disease, liver function classification, body mass index (BMI) and laboratory indexes, and analyzed the differences in the occurrence of complications, mortality rate and readmission rate after discharge. Logistic regression analysis was applied to identify the risk factors of hepatogenic diabetes mellitus and its adverse clinical manifestations.Results There were significant differences between the admission age, length of stay, course of disease and distribution of liver function of patients with simple cirrhosis and those with HD cirrhosis (P<0.05). There was no significant difference between the two groups in sex, etiology, BMI, hypersensitive-C-reactive protein (hs-CRP), Low-density lipoprotein and other clinical indexes (P>0.05). The follow-up time was 1 year and no death happened in both groups. There was 1 re-hospitalized case in control Group and 8 re-hospitalized cases in HD Group. The incidence of pulmonary infection in HD Group (35%) was significantly higher than that in control group (14.28%) (P<0.05). There was no significant difference between these two groups in the incidence of other complications (P>0.05). The Results of Logistic regression analysis showed that the course of disease and Child-Pugh grade C were risk factors of HD complication in liver cirrhosis (P<0.05).Conclusion There were significant differences in admission age, length of stay, course of disease and liver function between simple cirrhosis group and cirrhosis with HD group, the course of disease and the liver function of Child Pugh grade C were risk factors of liver cirrhosis complicated with hepatogenic diabetes. Cirrhotic patients with HD had higher risk of adverse clinical manifestations than those without.

Key words: Cirrhosis, Hepatogenic diabetes, Clinical manifestations, Prognosis