[1] 中华医学会肝病学分会脂肪肝和酒精性肝病学组,中国医师协会脂肪性肝病专家委员会.非酒精性脂肪性肝病防治指南(2018年更新版). 临床肝胆病杂志,2018,34:947-957. [2] Podszun MC, Alawad AS, Lingala S et al.Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis. Redox Biol,2020,37:101710. [3] Yu X, Hao M, Liu Y et al.Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy. Eur J Pharmacol,2019,864:172715. [4] Carotti S, Aquilano K, Zalfa F et al.Lipophagy Impairment Is Associated With Disease Progression in NAFLD. Front Physiol,2020,11:850. [5] Gao Y, Zhang W, Zeng LQ,et al.Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy. Redox Biol,2020,36:101635. [6] Chalasani N, Younossi Z, Lavine JE et al.The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology,2018,67:328-357. [7] Kani AH, Alavian SM, Esmaillzadeh A et al.Effects of a Low-Calorie, Low-Carbohydrate Soy Containing Diet on Systemic Inflammation Among Patients with Nonalcoholic Fatty Liver Disease: A Parallel Randomized Clinical Trial. Horm Metab Res,2017,49:687-692. [8] Asghari S, Asghari-Jafarabadi M, Somi MH et al.Comparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial. J Am Coll Nutr,2018,37:223-233. [9] Baldry EL, Aithal GP, Kaye P et al.Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: Results of a randomized controlled trial using 2 dietary approaches. Diabetes Obes Metab,2017,19:1179-1183. [10] Noakes TD, Windt J.Evidence that supports the prescription of low-carbohydrate high-fat diets: a narrative review. Br J Sports Med,2017,51:133-139. [11] Webster CC, Murphy TE, Larmuth KM et al. Diet, Diabetes Status, and Personal Experiences of Individuals with Type 2 diabetes Who Self-Selected and Followed a Low Carbohydrate High Fat diet. Diabetes Metab Syndr Obes,2019,12:2567-2582. [12] Mardinoglu A, Wu H, Bjornson E et al.An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. Cell Metab,2018,27:559-571 e555. [13] Xia MF, Bian H, Zhu XP et al.Serum folic acid levels are associated with the presence and severity of liver steatosis in Chinese adults.Clin Nutr,2018,37:1752-1758. [14] Ryan MC, Itsiopoulos C, Thodis T et al.The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease.J Hepatol,2013,59:138-143. [15] Abenavoli L, Greco M, Milic N et al.Effect of Mediterranean Diet and Antioxidant Formulation in Non-Alcoholic Fatty Liver Disease: A Randomized Study.Nutrients,2017,9:870. [16] Billingsley HE, Carbone S.The antioxidant potential of the Mediterranean diet in patients at high cardiovascular risk: an in-depth review of the PREDIMED.Nutr Diabetes,2018,8:13. [17] Musa-Veloso K, Venditti C, Lee HY et al.Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease.Nutr Rev,2018,76:581-602. [18] Abenavoli L, Boccuto L, Federico A et al.Diet and Non-Alcoholic Fatty Liver Disease: The Mediterranean Way.Int J Environ Res Public Health,2019,16:3011. [19] Le Roy T, Llopis M, Lepage P et al.Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice.Gut,2013,62:1787-1794. [20] Hoyles L, Fernandez-Real JM, Federici M et al.Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women.Nat Med,2018,24:1070-1080. [21] Aron-Wisnewsky J, Vigliotti C, Witjes J et al.Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders.Nat Rev Gastroenterol Hepatol,2020,17:279-297. [22] Chen J, Vitetta L.Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications.Int J Mol Sci,2020,21:5214. [23] Famouri F, Shariat Z, Hashemipour M et al.Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents.J Pediatr Gastroenterol Nutr,2017,64:413-417. [24] Asgharian A, Askari G, Esmailzade A et al.The Effect of Symbiotic Supplementation on Liver Enzymes, C-reactive Protein and Ultrasound Findings in Patients with Non-alcoholic Fatty Liver Disease: A Clinical Trial.Int J Prev Med,2016,7:59. [25] Nabavi S, Rafraf M, Somi MH et al.Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease.J Dairy Sci,2014,97:7386-7393. [26] Craven L, Rahman A, Nair Parvathy S et al.Allogenic Fecal Microbiota Transplantation in Patients With Nonalcoholic Fatty Liver Disease Improves Abnormal Small Intestinal Permeability: A Randomized Control Trial.Am J Gastroenterol,2020,115:1055-1065. [27] Farzanegi P, Dana A, Ebrahimpoor Z et al.Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation.Eur J Sport Sci,2019,19:994-1003. [28] Hallsworth K, Thoma C, Hollingsworth KG et al.Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial.Clin Sci (Lond),2015,129:1097-1105. [29] Abdelbasset WK, Tantawy SA, Kamel DM et al.Effects of high-intensity interval and moderate-intensity continuous aerobic exercise on diabetic obese patients with nonalcoholic fatty liver disease: A comparative randomized controlled trial.Medicine (Baltimore),2020,99:e19471. [30] Zhang HJ, He J, Pan LL et al.Effects of Moderate and Vigorous Exercise on Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial.JAMA Intern Med,2016,176:1074-1082. [31] Hashida R, Kawaguchi T, Bekki M et al.Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review.J Hepatol,2017,66:142-152. [32] Vilar Gomez E, Rodriguez De Miranda A, Gra Oramas B et al.Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease.Aliment Pharmacol Ther,2009,30:999-1009. [33] Khaoshbaten M, Gholami N, Sokhtehzari S et al.The effect of an aerobic exercise on serum level of liver enzymes and liver echogenicity in patients with nonalcoholic fatty liver disease.Gastroenterol Hepatol Bed Bench,2013,6(Suppl 1):S112-116. [34] Bacchi E, Negri C, Targher G et al.Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial.Hepatology,2013,58:1287-1295. [35] Fealy CE, Haus JM, Solomon TP et al.Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease.J Appl Physiol (1985),2012,113:1-6. [36] Haus JM, Solomon TP, Kelly KR et al.Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease.J Clin Endocrinol Metab,2013,98:E1181-1188. |