AMPK信号通路和NLRP3炎症小体在肝衰竭中的研究进展

摘要/Abstract

摘要： 肝衰竭是由多种因素导致的严重肝脏结构和功能损伤,且是一个涉及“三重打击”的复杂病理生理过程。在机体内,AMPK信号在调节细胞能量平衡中起着重要作用。肝脏作为机体的代谢工厂,对能量的产生和利用有着严格的调控。此外,NLRP3炎症小体也在众多炎症性疾病发生发展过程中扮演着重要角色。而AMPK信号通路和NLRP3小体之间存在交互影响。本文就AMPK介导的多种信号通路、NLRP3炎症小体的激活效应及二者之间的相互作用在肝衰竭过程中的研究进展做一综述。

关键词: 肝衰竭, 三重打击, AMPK信号通路, NLRP3炎症小体

陈倩, 张清奇, 龚作炯. AMPK信号通路和NLRP3炎症小体在肝衰竭中的研究进展[J]. 肝脏, 2023, 28(2): 244-246.

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