肝内胆管癌起源细胞的研究进展

摘要/Abstract

摘要： 肝内胆管癌(iCCA)是一种预后较差的上皮细胞起源的恶性肿瘤,其发病率和死亡率逐年上升。iCCA在组织形态及分子表达水平上呈现高度异质性,极大地阻碍了临床精准治疗的实施。肿瘤异质性的产生是多种复杂因素共同作用的结果,包括不同的致病因素、基因突变、分子表达谱及不同的起源细胞等。前期在小鼠模型中使用遗传谱系示踪系统明确了胆管上皮细胞、肝细胞或肝母细胞都可能是iCCA的起源细胞。最新研究发现,人肝细胞在原癌基因驱动下结合药物诱导的肝损伤微环境,可以诱导肝内胆管癌的发生。这一发现丰富了iCCA起源细胞的来源,同时为深入解析iCCA亚群的发病机制提供了新的研究平台。本文简要回顾了肝内胆管癌起源细胞的相关研究,包括病理分析,不同起源介绍,驱动因素分析,期望对iCCA的临床精准诊疗提供指导和借鉴。

关键词: 肝内胆管癌, 起源细胞, 胆管细胞, 肝细胞, 肝母细胞

刘文明, 张秋秋, 鄢和新. 肝内胆管癌起源细胞的研究进展[J]. 肝脏, 2024, 29(11): 1309-1311.

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