HBeAg阳性慢性乙型肝炎患者CD55单核苷酸多态性对聚乙二醇化干扰素α-2b疗效的影响

肝脏 ›› 2024, Vol. 29 ›› Issue (11): 1374-1377.

HBeAg阳性慢性乙型肝炎患者CD55单核苷酸多态性对聚乙二醇化干扰素α-2b疗效的影响

陈继良, 周婉月, 徐铭晨

223900 江苏泗洪县第一人民医院检验科(陈继良),感染科(徐铭晨);223899 南京医科大学附属宿迁第一人民医院检验科(周婉月)

收稿日期:2024-05-13 出版日期:2024-11-30 发布日期:2025-01-10
通讯作者: 徐铭晨,Email:408282240@qq.com
基金资助:
江苏省卫生健康委基金项目(ZD2022041)

Effect of CD55 single nucleotide polymorphism on the efficacy of pegylated interferon α-2b in chronic hepatitis B patients with HBeAg-positive

CHEN Ji-liang¹, ZHOU Wan-yue², XU Ming-chen³

1. Department of Laboratory, Sihong First People’s Hospital, Jiangsu 223900,China;
2. Department of Laboratory, Nanjing Medical University Affiliated Suqian First People’s Hospital, Suqian, Jiangsu 223899,China;
3. Department of Infectious Diseases, Sihong First People’s Hospital, Jiangsu 223900,China

Received:2024-05-13 Online:2024-11-30 Published:2025-01-10
Contact: XU Ming-chen,Email:408282240@qq.com

摘要/Abstract

摘要： 目的探讨CD55单核苷酸多态性(CD55-SNP)对HBeAg阳性慢性乙型肝炎(CHB)接受聚乙二醇化干扰素α-2b(Peg-IFNα-2b)治疗的影响。方法选取2017年8月—2021年8月期间入院诊治HBeAg阳性CHB患者159例。根据HBV DNA＜2000 IU/mL且HBsAg和抗-HBe血清转换者结果分为应答组(87例)和非应答组(72例)。回顾性分析两组患者的临床资料,探究CD55-SNP对患者治疗的影响。结果 CD55- rs28371597 在应答组的GG基因(91.4%)明显高于CT基因(6.4%)和TT基因(3.2%),CFB-rs12614 CC基因(92.4%)显著高于CT基因(7.6%)和TT基因,(0%),STAT4-rs7574865 GG基因(52.6%)明显高于GT基因(38.1%)和TT基因(9.3%)。与非应答组(75.0%、79.1%)相比,应答组的CD55-rs28371597 GG基因(91.4%)和CFB-rs12614 CC基因(92.4%)升高。对患者根据治疗效果的影响因素进行分析,两组患者的饮酒、CD55-rs28371597基因型比较差异有统计学意义。HBV DNA、CFB-rs12614和STAT4-rs7574865经多变量校正发现不影响治疗结局,差异无统计学意义(P>0.05),而CD55-rs28371597显著影响治疗结局(P<0.05)。结论 CD55-SNP 多态性影响HBeAg阳性CHB患者接受治疗Peg-IFNα-2b的疗效,且与病毒学应答紧密相关,临床医生可根据CD55-SNP 多态性分布情况,预测Peg-IFNα-2b治疗效果,给予合理的治疗方案。

关键词: CD55单核苷酸多态性, HBeAg, 慢性乙型肝炎, 聚乙二醇化干扰素α-2b, 疗效

Abstract: Objective To investigate the effect of CD55 single nucleotide polymorphism (CD55-SNP) on the efficacy of pegylated interferon α-2b (Peg-IFNα-2b) in chronic hepatitis B (CHB) patients with HBeAg-positive. Methods From August 2017 to August 2021, 159 CHB patients with HBeAg-positive were selected. According to the results, CHB patients were divided into response group and non-response group. The clinical data of the two groups were retrospectively analyzed to explore the effect of CD55-SNP on the treatment of patients. Results The GG gene (91.4%) of CD55- rs28371597 was significantly higher than that of CT gene (6.4%) and TT gene (3.2%), and the CFB-rs12614 CC gene (92.4%) was significantly higher than that of CT gene (7.6%) and TT gene (0%) in the response group. Compared with the non-response group (75.0%, 79.1%), the CD55-rs28371597 GG gene (91.4%) and CFB-rs12614 CC gene (92.4%) in the response group increased. According to the analysis of the influencing factors of the treatment effect, the comparison of drinking and CD55-rs28371597 genotype between the two groups was statistically significant. After multivariate calibration, HBV DNA, CFB-rs12614 and STAT4-rs7574865 did not affect the treatment outcome (P>0.05), while CD55-rs28371597 significantly affected the treatment outcome (P<0.05). Conclusion CD55-SNP polymorphism affects the efficacy of Peg-IFNα-2b in CHB patients with HBeAg-positive, and is closely related to virological response. Clinicians can predict the therapeutic effect of Peg-IFNα-2b according to the distribution of CD55-SNP polymorphism and give a reasonable treatment plan.

Key words: CD55 single nucleotide polymorphism, HBeAg, Chronic hepatitis B, Pegylated interferon α-2b, Therapeutic effect

陈继良, 周婉月, 徐铭晨. HBeAg阳性慢性乙型肝炎患者CD55单核苷酸多态性对聚乙二醇化干扰素α-2b疗效的影响[J]. 肝脏, 2024, 29(11): 1374-1377.

CHEN Ji-liang, ZHOU Wan-yue, XU Ming-chen. Effect of CD55 single nucleotide polymorphism on the efficacy of pegylated interferon α-2b in chronic hepatitis B patients with HBeAg-positive[J]. Chinese Hepatolgy, 2024, 29(11): 1374-1377.

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