固有免疫细胞在急性肝衰竭发生和发展中的作用及研究进展

摘要/Abstract

摘要： 急性肝衰竭(ALF)是一种高病死率的临床危重病,其特征是无基础肝病患者的肝功能进行性恶化,常伴有黄疸、凝血功能障碍和肝性脑病。ALF的发病机制很复杂,尚未完全阐明。嗜肝病毒、药物毒物、自身免疫性疾病、缺血等不同病因均可引起急性肝损伤,可迅速进展为ALF甚至死亡,目前尚无特效治疗药物和方法。因此,深入探究ALF的发病机制并寻找有效的治疗方法显得尤为重要。本文综述了ALF相关的固有免疫机制,以及固有免疫细胞在ALF发生和发展过程中的作用。

王小燕, 张雨夜, 田李均, 韩旭东. 固有免疫细胞在急性肝衰竭发生和发展中的作用及研究进展[J]. 肝脏, 2024, 29(3): 358-362.

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