超声引导下经皮经肝穿刺肝活检组织长度的影响因素

肝脏 ›› 2025, Vol. 30 ›› Issue (10): 1406-1409.

超声引导下经皮经肝穿刺肝活检组织长度的影响因素

李俊缨, 程笑, 朱幼芙, 吴爱华, 陈金军

511300 广州南方医院增城院区(李俊缨,程笑);510515 广州南方医科大学南方医院感染内科(陈金军,朱幼芙,吴爱华)

收稿日期:2024-11-04 出版日期:2025-10-31 发布日期:2025-12-16
通讯作者: 陈金军,Email: chjj@smu.edu.cn
基金资助:
国家重点研发计划(2022YFC2304800),国家自然科学基金(82370614,82070650),国家科技重大专项(2018ZX10723203),广东珠江人才计划地方创新科研团队项目(2017BT01S131),南方医科大学南方医院临床科研计划(2020CR026),广东省教育厅高水平大学建设基金南方医科大学临床研究启动计划(LC2019ZD006),广东省重点领域研发计划(2019B020227004)。

Influencing factors of tissue length in ultrasound-guided percutaneous transhepatic liver biopsy

LI Jun-ying¹, CHENG Xiao¹, ZHU You-fu², WU Ai-hua², CHEN Jin-jun²

1. Hepatology Unit, Zengcheng Branch, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;
2. Department of and Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

Received:2024-11-04 Online:2025-10-31 Published:2025-12-16
Contact: CHEN Jin-jun, Email:chjj@smu.edu.cn

摘要/Abstract

摘要： 目的探讨超声引导下经皮经肝活检组织长度的影响因素。方法纳入南方医院增城院区2019年1月至2024年3月超声引导下经皮经肝活检患者625例。收集患者人口学、生化指标、穿刺针类型、穿刺术后并发症等指标,比较单条组织长度＜15 mm、≥15 mm两组,单条组织长度＜15 mm、15~19 mm、≥20 mm三组上述指标差异。应用logistic多因素回归分析评估单条穿刺组织长度的风险因素。结果单条组织长度＜15 mm组与≥15 mm组相比,单条组织长度≥15 mm组组织平均长度为17.8 mm,<15 mm组组织平均长度仅为11.4 mm。且≥15 mm组全芯针占比更多(45.8%),穿刺年资≥1年医生占比更高(65.3%), 腹部疼痛占比更少(4.5%)。单条组织长度＜15 mm组与15~19 mm组、≥20 mm组相比,组织长度越长,全芯针占比和穿刺年资≥1年医生占比更高(P＜0.05)。单条组织长度＜15 mm组与15~19 mm组相比,腹痛占比更少(9.6%比3.6%,P=0.005)。单条组织长度＜15 mm组与≥20 mm组相比,脾硬度更高(P=0.03)。全芯活检针是超声引导下经皮经肝穿刺活检单条组织长度的独立保护性因素。女性、年轻、组织长度更短、术前及术后Hb更低患者发生腹痛占比更多。结论全芯活检针是超声引导下经皮经肝穿刺活检单条组织长度的独立保护性因素。

关键词: 组织长度, 肝活检针, 超声引导下肝穿刺活检, 经皮经肝穿刺

Abstract: Objective To investigate the influencing factors of tissue length in ultrasound-guided percutaneous transhepatic biopsy. Methods 625 patients underwent ultrasound guided percutaneous by liver biopsy in Nanfang hospital zengcheng Branch between January 2019 and March 2024 were analyzed retrospectively. Patients′ demographic, biochemical indexes, the types of needle, indicators such as complications after paracentesis were collected. The differences of the above indexes between the two groups of single tissue length < 15 mm or ≥15 mm, and the three groups of single tissue length < 15 mm, 15-19 mm and ≥20 mm were compared. Logistic multivariate regression analysis was used to analyze the risk factors of the length of single puncture tissue. The differences of abdominal pain and minor bleeding between the two groups were evaluated. Results The mean specimen length was 11.4 mm in the <15 mm group and 17.8 mm in the ≥15 mm group. The ≥15 mm group had a significantly higher proportion of procedures performed with a full-core needle (45.8%) and by operators with more than one year of experience (65.3%), but a lower incidence of abdominal pain (4.5%). Among the three subgroups (<15 mm, 15~19 mm, ≥20 mm), the use of full-core needles and operators with ≥1 year of experience significantly increased with greater specimen length (P<0.05 for trend). Length of a single tissue < 15 mm and 15-19 mm group, the higher length group accounted for less proportion of abdominal pain (3.6%, P=0.005). Length of a single tissue < 15 mm group and ≥20 mm group, shorter length of group in spleen hardness is higher. The full-core needle is an independent protective factor for the length of single tissue in ultrasound-guided percutaneous transhepatic biopsy. Compared two groups of abdominal pain, female, younger, length is shorter, lower preoperative and postoperative Hb statistic in patients were account for more painful. Conclusion The full-core needle is an independent protective factor for the length of single tissue in ultrasound-guided percutaneous transhepatic biopsy.

Key words: Tissue length, Liver biopsy needle, Ultrasound-guided liver biopsy, Percutaneous by liver biopsy

李俊缨, 程笑, 朱幼芙, 吴爱华, 陈金军. 超声引导下经皮经肝穿刺肝活检组织长度的影响因素[J]. 肝脏, 2025, 30(10): 1406-1409.

LI Jun-ying, CHENG Xiao, ZHU You-fu, WU Ai-hua, CHEN Jin-jun. Influencing factors of tissue length in ultrasound-guided percutaneous transhepatic liver biopsy[J]. Chinese Hepatolgy, 2025, 30(10): 1406-1409.

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