关键词: 肝硬化, 病因, 流行病学, 并发症

Abstract: Objective To provide reference for prevention and treatment of cirrhosis in Chinese people in the new era by analyzing the epidemiological characteristics and changes of different types of cirrhosis in recent five years.Methods A total of 2201 patients with cirrhosis were collected from January 2017 to December 2021 in the first People's Hospital of Mianyang city, Sichuan, China. Fisher's Exact Test was used to analyze the differences of age, sex, etiology and complications in patients with cirrhosis, and to analyze the alteration trends in etiologies.Results The average age of 2201 patients with cirrhosis was (58.64 ± 12.78) years, among them, the age of post-hepatitis B cirrhosis was the youngest (55.23 ± 11.58 years), and the age of Alcoholic cirrhosis was the oldest (68.67 ± 11.02 years). Most of the patients with cirrhosis were male (69.70%), and most of them were post-hepatitis B cirrhosis and Alcoholic cirrhosis. The ratio of male to female in Autoimmune cirrhosis was inversely proportional (1∶3.52) . The most common etiology of cirrhosis was hepatitis B-related cirrhosis (1238 cases, 56.25%), followed by Alcoholic cirrhosis (177 cases, 8.04%), cirrhosis caused by Schistosomiasis has been decreasing in recent two years. The common complications of cirrhosis were Spontaneous bacterial peritonitis (23.53%), primary liver cancer (20.45%), Upper gastrointestinal bleeding (13.63%) and Hepatic encephalopathy (7.31%). Among them, Spontaneous bacterial peritonitis was common in hepatitis B-related cirrhosis (30.29%) and alcoholic cirrhosis (22.03%), primary liver cancer was common in hepatitis B-related cirrhosis (28.11%) and hepatitis C-related cirrhosis (18.99%) .The most common Upper gastrointestinal bleeding were hepatitis C-related cirrhosis (18.35%) and autoimmune cirrhosis (11.11%) .Conclusion At present, the epidemiological characteristics of cirrhosis in our country are changing. The type of hepatitis B-related cirrhosis is still the most common, yet the trend is decreasing year by year. On the contrary, the trend of alcoholic cirrhosis is increasing year by year. Spontaneous bacterial peritonitis and primary liver cancer are the most common complications of cirrhosis, The incidences of different complications in patients with different etiologies of cirrhosis are however significantly different.

Key words: Cirrhosis, Etiology, Epidemiology, Complications