新生儿脐静脉置管发生肝功能异常影响因素

摘要/Abstract

摘要： 目的分析新生儿脐静脉置管(UVC)发生肝功能异常的影响因素,为临床预防和治疗提供理论依据。方法对晋城市人民医院2023年2月—2024年11月收治的82例接受脐静脉置管的新生儿进行分析,收集胎龄、置管留置时间、Apgar评分＜7分、PICC治疗史、置管深度等资料,根据有无发生肝功能异常分为两组,比较两组新生儿基础资料,分析新生儿UVC致肝功能异常的影响因素。结果肝功能异常组Apgar评分＜7分68.75%(11/16)、PICC治疗史68.75%(11/16)、置管深度(5.20±0.63)cm高于无肝功能异常组28.13%(18/66)、30.30%(20/66)、(3.24±0.45)cm,胎龄(33.52±1.52)周低于无肝功能异常组(35.74±2.03)周,置管留置时间(17.13±2.85)d长于无肝功能异常组(14.24±2.34)d(P<0.05)。经二元logistic回归分析,Apgar评分＜7分[OR=5.867(95%CI:1.789~19.243)]、置管深度[OR=7.546(95%CI:2.579~22.0767)]、置管留置时间[OR=1.574(95%CI:1.121~2.044)]、PICC治疗史[OR=5.060(95%CI:1.554~16.472)]是新生儿UVC发生肝功能异常的危险因素,胎龄[OR=0.512(95%CI:0.344~0.761)]是新生儿UVC肝功能异常的保护因素(P<0.05)。结论置管留置时间、PICC治疗史、Apgar评分＜7分、胎龄、置管深度是新生儿UVC发生肝功能异的影响因素。

关键词: 新生儿, 脐静脉置管, 肝功能异常, 影响因素

Abstract: Objective To analyze the influential factors of abnormal liver function in newborns with umbilical vein catheterization (UVC), and to provide theoretical basis for clinical prevention and treatment. Methods A total of 82 neonates receiving umbilical vein catheterization admitted to Jincheng People′s Hospital from February 2023 to November 2024 were selected. Gestational age, catheterization retention time, Apgar score < 7, PICC treatment history, catheterization depth and other data were collected. They were divided into two groups according to whether abnormal liver function occurred, and the basic data of neonates in the two groups were compared. To analyze the multiple factors of liver dysfunction caused by neonatal UVC. Results Apgar score < 7 68.75% (11/16), PICC treatment history 68.75% (11/16), catheterization depth (5.20±0.63) cm in the group with abnormal liver function were higher than those in the group without abnormal liver function 28.13% (18/66), 30.30% (20/66), (3.24±0.45) cm. The gestational age of (33.52±1.52) weeks was lower than that of the group without hepatic dysfunction (35.74±2.03) weeks, and the retention time of catheterization (17.13±2.85) d was longer than that of the group without hepatic dysfunction (14.24±2.34) d (P<0.05). Binary Logistic regression analysis showed that Apgar score < 7 [OR=5.867 (95%CI: 1.789~19.243)], catheterization depth [OR=7.546 (95%CI: 2.579~22.0767)], catheterization retention time [OR=1.574 (95%CI: 1.121~2.044)], PICC treatment history [OR=5.060 (95%CI: 1.554~16.472)] were risk factors for liver dysfunction of neonatal UVC, and gestational age [OR=0.512 (95%CI: 0.344~0.761)] was a protective factor for neonatal UVC liver dysfunction (P<0.05). Conclusion Catheterization retention time, PICC treatment history, Apgar score <7, gestational age and catheterization depth are the influential factors for the abnormal liver function of neonatal UVC.

Key words: Newborn, Umbilical vein catheterization, Abnormal liver function, Influencing factor

程向宁, 常晓, 王晓芳. 新生儿脐静脉置管发生肝功能异常影响因素[J]. 肝脏, 2025, 30(7): 996-999.

CHENG Xiang-ning, CHANG Xiao, WANG Xiao-fang. Factors influencing abnormal liver function in newborns with umbilical vein catheterization[J]. Chinese Hepatolgy, 2025, 30(7): 996-999.

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