基于肠-肝轴理论探讨NAFLD进展与肠道菌群的联系

摘要/Abstract

摘要： 非酒精性脂肪性肝病(NAFLD)是世界范围内最常见的肝脏疾病之一,影响全球30%的人口,可以表现为单纯性脂肪变性、非酒精性脂肪性肝炎(NASH)、肝纤维化、肝硬化或肝细胞癌(HCC) ,后期严重影响患者的生活质量。然而多项研究结果均表明,肠道菌群失调可参与对肝脏的多重攻击,并在NAFLD的发病机制中起关键作用。本文重点讨论了基于肠-肝轴理论,肠道菌群与NAFLD不同进展阶段的关联,探讨其在NAFLD治疗中的潜在意义。

敬进华, 金星, 马旭, 张福礼, 赵雪静, 毕刚, 戴伯华, 刘瑛, 郭峰, 丁国宁. 基于肠-肝轴理论探讨NAFLD进展与肠道菌群的联系[J]. 肝脏, 2024, 29(9): 1150-1153.

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