关键词: 肝炎, 乙型, 慢性, 肾小球滤过率, 肌酐

Abstract: Objective To investigate the correlations of glomerular filtration rate（GFR）with age,creatinine level and other factors in chronic hepatitis B patients.Methods GFR was detected in a total of 1060 patients,including 228 people as contrast group,563 people as chronic hepatitis（CH）group,98 people as early liver cirrhosis（ELC）group,41 people as hepatocellular carcinoma（HCC）group,and 130 people as decompensated liver cirrhosis（HLC）group.Chisquare test,independent sample t-test and bivariate Pearson correlation analysis were applied in the study by SPSS 19.0.Results In contrast group,CH group,ELC group,HCC group and HLC group,there were 38（16.8%）and 4（1.7%）,108（19.2%）and 3（0.5%）,26（26.5%）and 6（6.1%）,8（19.5%）and 0（0%）,and 43（33.1%）and 16（12.3%）patients with mildly and moderately decreased GFR,respectively.Among all those 832 patients with chronic hepatitis B,the correlation coefficients of age,creatinine,urea nitrogen and uric acid with GFR were–0.369,–0.597,–0.282 and–0.2,respectively.Conclusion GFR is more accurate in assessing renal function impairment,especially for early and mild renal dysfunction.Influence of nucleoside analogues on GFR in chronic hepatitis B patients should be paid more attention.Additionally,both GFR and blood phosphorus test play indispensable roles in clinical practice and cannot replace one another.

Key words: Chronic hepatitis B, Glomerular filtration rate, Creatinine