血清HBV RNA预测慢性乙型肝炎患者停药后复发的meta分析

摘要/Abstract

摘要： 目的分析血清HBV RNA在预测慢性乙型肝炎患者停药后复发方面的意义,为寻找指导安全停药的新型血清学标志物提供依据。方法检索PubMed、Embase、Web of science、Cochrane library和https://clinicaltrials.gov/并获取2016年至2020年期间发表的相关英文文献;同时进行手工检索。严格按照纳入及排除标准进行文献筛选,对最终纳入的文献进行数据提取及质量评价,使用Revman 5.3软件对获取的数据进行meta分析。结果 Meta分析结果显示,相比于血清HBV RNA阴性患者,停药时血清HBV RNA阳性患者停药后面临更高的临床复发风险(RR=2.98, 95%CI=1.55~5.72, P=0.001)。结论血清HBV RNA是协助预测停药后临床复发的一个重要生物学标志物。未来血清HBV RNA在预测抗病毒治疗后停药复发方面的意义值得进一步研究。

关键词: 慢性乙型肝炎, 血清HBV RNA, 前基因组RNA, meta分析

Abstract: Objective To investigate the predictive value of serum hepatitis B virus (HBV) RNA on relapse in patients with chronic hepatitis B (CHB) after withdrawal of antiviral therapy, and to screen a new biomarker for safely drug withdrawl.Methods PubMed, Embase, Web of science, Cochrane library and https://clinicaltrials.gov/ were used to search for relevant English articles published from 2016-2020. Manual searching was also conducted. The articles were screened according to the inclusion and exclusion criteria. Data extraction and quality assessment were also performed in the involved articles. Revman 5.3 software was used for meta-analysis.Results Compared with HBV RNA-negative patients, serum HBV RNA-positive patients had a higher risk of clinical relapse after drug withdrawal (RR=2.98, 95%CI=1.55~5.72, P=0.001).Conclusion Serum HBV RNA is an important assistant biomarker for predicting clinical relapse after drug withdrawal in patients with CHB. And the predicting value of serum HBV RNA on HBV recurrence after drug withdrawl deserves further investigation.

Key words: Chronic hepatitis B, Serum hepatits B virus RNA, Pregenomic RNA, Meta-analysis

张琪, 王余彦, 秦波. 血清HBV RNA预测慢性乙型肝炎患者停药后复发的meta分析[J]. 肝脏, 2022, 27(6): 647-651.

ZHANG Qi, WANG Yu-yan, QIN Bo. Predictive value of serum HBV RNA on relapse in patients with chronic hepatitis B after withdrawal of antiviral therapy: a meta-analysis[J]. Chinese Hepatolgy, 2022, 27(6): 647-651.

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