氧化应激与妊娠期肝内胆汁淤积症相关性研究进展

摘要/Abstract

摘要： 妊娠期肝内胆汁淤积症(ICP)是一种常见的妊娠期特发性疾病,主要表现为皮肤瘙痒和血清总胆汁酸水平升高,其病因尚不明确。ICP于孕妇是一种良性疾病,但对围产儿可能造成严重的不良影响。近年来,越来越多的研究证据表明,氧化应激(OS)参与胚胎着床、发育、妊娠维持等过程,在妊娠和妊娠并发症中发挥重要作用。OS是机体氧化－抗氧化系统失衡的一种状态,对细胞的增殖、分化、凋亡至关重要。本文综述了近年来OS在ICP发病中的研究进展,以及其在病因和预防中的作用。

关键词: 妊娠期肝内胆汁淤积症, 胆汁酸, 氧化应激, 自噬

陈玲燕, 刘嘉玉, 李京阳, 顾颖, 张岩. 氧化应激与妊娠期肝内胆汁淤积症相关性研究进展[J]. 肝脏, 2023, 28(9): 1116-1118.

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