肿瘤相关巨噬细胞在肝癌免疫治疗中的研究进展

摘要/Abstract

摘要： 肝细胞癌治疗手段有限,5年生存率较低,随着对肿瘤微环境认识的不断深入,肿瘤相关巨噬细胞(TAM)在肿瘤微环境中的独特作用使其在抗肿瘤治疗中展现出良好前景。TAM可分为抗肿瘤M1亚型和促肿瘤M2亚型,在肿瘤发生的调节和进展中起着至关重要的作用。研究表明,减少TAM的数量或改变TAM的极化可以抑制肿瘤的生长,提示TAM可能成为肿瘤治疗的潜在靶点。本文综述了肝癌中TAM的起源、极化和功能,以及其在肝癌治疗中的研究进展,为进一步开展TAM的临床研究提供理论基础。

王海玉, 李波, 高敬涵, 童金龙. 肿瘤相关巨噬细胞在肝癌免疫治疗中的研究进展[J]. 肝脏, 2025, 30(9): 1287-1292.

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