卡瑞利珠单抗联合TACE治疗不可切除肝癌的疗效

肝脏 ›› 2026, Vol. 31 ›› Issue (4): 532-535.

卡瑞利珠单抗联合TACE治疗不可切除肝癌的疗效

李春玲, 张晓娟, 宋燕齐, 程丽, 牛博宇

056000 邯郸邯郸市中西医结合医院药剂科(李春玲,张晓娟,宋燕齐,程丽),药材科(牛博宇)

收稿日期:2025-08-10 出版日期:2026-04-30 发布日期:2026-06-04
通讯作者: 牛博宇,Email:449126023@qq.com
基金资助:
河北省中医药管理计划项目(2025607)

Clinical efficacy of camrelizumab combined with TACE in the treatment of unresectable hepatocellular carcinoma

LI Chun-ling¹, ZHANG Xiao-juan¹, SONG Yan-qi¹, CHENG LI¹, NIU Bo-yu²

1. Department of Pharmacy, Handan Hospital of Integrated Traditional Chinese and Western Medicine, Handan 056000, China;
2. Department of Medicinal Materials, Handan Hospital of Integrated Traditional Chinese and Western Medicine, Handan 056000, China

Received:2025-08-10 Online:2026-04-30 Published:2026-06-04
Contact: NIU Bo-yu,Email:449126023@qq.com

摘要/Abstract

摘要： 目的分析卡瑞利珠单抗联合经肝动脉化疗栓塞术(TACE)对肝细胞癌(HCC)的临床效果。方法选取 2021 年 9 月至 2022 年 9 月邯郸市中西医结合医院收治的HCC患者 90 例,采用 TACE 单一治疗和采用卡瑞利珠单抗联合 TACE 治疗各45例。比较临床疗效、血清PEG10、CA15-3、AFP水平变化及生存情况,评估不良反应发生率。结果治疗6个月后,联合治疗组客观缓解率和疾病控制率分别为73.3%(33/45)和93.3%(42/45),显著高于单一治疗组的46.7%(21/45)和80.0%(36/45)(P<0.05);联合治疗组治疗后血清PEG10、CA15-3、AFP水平分别为(519.4±65.1)ng/L、(7.6±1.0)U/mL和(313.2±22.2)μg/L,显著低于单一治疗组的(550.6±69. 3)ng/L、(10.1±1.2)U/mL、(327.0±27.2)μg/L(P<0.05)。随访30个月,联合治疗组中位总生存期(26.7个月)和中位无进展生存期(21.0个月)均显著长于单一治疗组(21.4个月、15.9个月)(P<0.05)。两组1、2级不良反应(57.8%比66.7%)和3、4级不良反应(26.7%比20.0%)发生率比较差异均无统计学意义(P>0.05)。结论卡瑞利珠单抗联合TACE能改善HCC患者临床疗效,延长生存时间,且安全性良好。

关键词: 肝细胞癌, 卡瑞利珠单抗, 肝动脉化疗栓塞, 生存分析, 安全性

Abstract: Objective To investigate the clinical efficacy, survival prognosis, and safety of camrelizumab combined with transarterial chemoembolization (TACE) in patients with primary hepatocellular carcinoma (HCC). Methods A total of 90 patients with HCC admitted to our hospital from September 2021 to September 2022 were selected and divided into two groups by random number table method. There were 45 cases in each of the control group (treated with TACE alone) and the study group (treated with camrelizumab combined with TACE). The two groups underwent comparison regarding clinical efficacy, variations in serum PEG10, CA15-3 and AFP concentrations, survival results, and the incidence of adverse events. Results After 6 months of treatment, the objective response rate (ORR) and disease control rate (DCR) in the study group were 73.3% and 93.3%, respectively, significantly higher than those in the control group (46.7% and 80.0%, P<0.05). Post-treatment serum levels of PEG10, CA15-3, and AFP in the study group were (519.4±65.1) ng/L, (7.6±1.0) U/mL, and (313.2±22.2) μg/L, respectively, significantly lower than those in the control group [(550.6±69.3) ng/L, (10.1±1.2) U/mL, and (327.0±27.2) μg/L; P<0.05]. During a 30-month follow-up, the median overall survival (OS) and median progression-free survival (PFS) were significantly longer in the study group (26.7 months and 21.0 months) than in the control group (21.4 months and 15.9 months) (P<0.05). The incidence rates of grade 1、2 (57.8% vs. 66.7%) and grade 3、4 (26.7% vs. 20.0%) adverse events did not differ significantly between the two groups (P>0.05). Conclusion Camrelizumab combined with TACE significantly improves clinical efficacy and prolongs survival in patients with primary HCC, with an acceptable safety profile.

Key words: Hepatocelluar carcinoma, Camrelizumab, Transarterial chemoembolization, Survival analysis, Safety

李春玲, 张晓娟, 宋燕齐, 程丽, 牛博宇. 卡瑞利珠单抗联合TACE治疗不可切除肝癌的疗效[J]. 肝脏, 2026, 31(4): 532-535.

LI Chun-ling, ZHANG Xiao-juan, SONG Yan-qi, CHENG LI, NIU Bo-yu. Clinical efficacy of camrelizumab combined with TACE in the treatment of unresectable hepatocellular carcinoma[J]. Chinese Hepatolgy, 2026, 31(4): 532-535.

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